Our research program primarily focuses on the use of electron microscopic techniques to determine the structures of molecules, cells and tissues in 3D at high resolution. We also develop new methods and technologies for 3D EM imaging.
- In 3D cellular imaging, our main interest lies in using focused ion beam scanning electron microscopy (FIB-SEM), correlated with a variety of light microscopy techniques, to visualize cells and tissues in 3D at high resolution.
- We are primarily interested in using cryo-electron microscopy to determine high-resolution structures of macromolecular complexes. Recent work in the cryo-EM area has included the structures of both soluble and membrane-integral complexes to near-atomic resolution.
- The development of new methods for high resolution imaging by EM and new algorithms for data analysis is a key element of our research program.